Pharmacodynamics Modeling To Optimize Dosage Regimens of Sulbactam | Zendy

Sutep Jaruratanasirikul | Zendy; Wibul Wongpoowarak | Zendy; Nanchanit Aeinlang | Zendy; Monchana Jullangkoon | Zendy

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Pharmacodynamics Modeling To Optimize Dosage Regimens of Sulbactam

Author(s) -

Sutep Jaruratanasirikul,

Wibul Wongpoowarak,

Nanchanit Aeinlang,

Monchana Jullangkoon

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00342-13

Subject(s) - pharmacodynamics , pharmacology , sulbactam , pharmacokinetics , medicine , chemistry , antibiotics , biochemistry , antibiotic resistance , imipenem

The aim of this study was to reveal population pharmacokinetics and assess the efficacies of various dosage regimens of sulbactam in terms of the probability of target attainment with this agent over a range of MICs. Monte Carlo simulations were performed to determine the probability of attaining specific pharmacodynamic targets. The results indicated that a regimen consisting of a 4-h infusion of 3 g of sulbactam every 8 h would be an alternative treatment option for less-susceptible pathogens.

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