Generation of a Reporter Cell Line for Detection of Infectious Varicella-Zoster Virus and Its Application to Antiviral Studies | Zendy

Guanqing Wang | Zendy; Tatsuo Suzutani | Zendy; Yumiko Yamamoto | Zendy; Yoshiko Fukui | Zendy; Naoki Nozawa | Zendy; D. Scott Schmid | Zendy; Ichiro Kurane | Zendy; Naoki Inoue | Zendy

Open Access

Generation of a Reporter Cell Line for Detection of Infectious Varicella-Zoster Virus and Its Application to Antiviral Studies

Author(s) -

Guanqing Wang,

Tatsuo Suzutani,

Yumiko Yamamoto,

Yoshiko Fukui,

Naoki Nozawa,

D. Scott Schmid,

Ichiro Kurane,

Naoki Inoue

Publication year - 2006

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00342-06

Subject(s) - varicella zoster virus , virology , cell culture , virus , biology , cell , genetics

To simplify the titration of infectious varicella-zoster virus (VZV), we generated a reporter cell line that produced luciferase in a dose-dependent manner upon infection with cell-free VZV. A few VZV-infected cells were detectable by coculturing with the cell line. We demonstrated the usefulness of the cell line for antiviral studies.

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