Identification of a Novel NDM Variant, NDM-13, from a Multidrug-Resistant Escherichia coli Clinical Isolate in Nepal | Zendy

Basudha Shrestha | Zendy; Tatsuya Tada | Zendy; Tohru MiyoshiAkiyama | Zendy; Kayo Shimada | Zendy; Hiroshi Ohara | Zendy; Teruo Kirikae | Zendy; Bharat Mani Pokhrel | Zendy

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Identification of a Novel NDM Variant, NDM-13, from a Multidrug-Resistant Escherichia coli Clinical Isolate in Nepal

Author(s) -

Basudha Shrestha,

Tatsuya Tada,

Tohru MiyoshiAkiyama,

Kayo Shimada,

Hiroshi Ohara,

Teruo Kirikae,

Bharat Mani Pokhrel

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00332-15

Subject(s) - escherichia coli , microbiology and biotechnology , multiple drug resistance , cefotaxime , ertapenem , biology , new delhi , enterobacteriaceae , genetics , drug resistance , antibiotics , medicine , gene , metropolitan area , pathology

A novel New Delhi metallo-β-lactamase, NDM-13, was identified in a carbapenem-resistantEscherichia coli clinical isolate obtained from the urine of a patient in Nepal. The enzymatic activity of NDM-13 against β-lactams was similar to that of NDM-1. However, NDM-13 displayed significantly higherk cat /Km ratios for cefotaxime. The genetic environment ofbla NDM-13 was determined to betnpA -IS30-bla NDM-13 -ble MBL -trpF-dsbC-cutA-groES-groL , withbla NDM-13 located within the chromosome.

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