First Outbreak of a Plasmid-Mediated Carbapenem-Hydrolyzing OXA-48 β-Lactamase in Klebsiella pneumoniae in Spain | Zendy

Cristina Pitart | Zendy; Mar Solé | Zendy; Ignasi Roca | Zendy; Anna Fàbrega | Zendy; Jordi Vilà | Zendy; Francesc Marco | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

First Outbreak of a Plasmid-Mediated Carbapenem-Hydrolyzing OXA-48 β-Lactamase in Klebsiella pneumoniae in Spain

Author(s) -

Cristina Pitart,

Mar Solé,

Ignasi Roca,

Anna Fàbrega,

Jordi Vilà,

Francesc Marco

Publication year - 2011

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00329-11

Subject(s) - klebsiella pneumoniae , microbiology and biotechnology , outbreak , plasmid , biology , carbapenem , enterobacteriaceae , klebsiella infections , klebsiella , virology , antibiotics , escherichia coli , gene , genetics

TwentyKlebsiella pneumoniae isolates producing OXA-48 were collected from April 2009 to September 2010. Strains were clonally related and coproduced a CTX-M-15 β-lactamase. A conjugative plasmid of circa 70 kb carryingbla OXA-48 was identified. Eleven isolates showed low-level resistance to carbapenems, whereas nine showed high-level resistance. Decreased expression of OmpK36 was related to high-level resistance to carbapenems. The isolates belonged to sequence type 101 (ST101). This is the first outbreak caused by an OXA-48-producingK. pneumoniae strain in Spain.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research