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Doravirine is a novel nonnucleoside reverse transcriptase inhibitor in development for use with other antiretroviral therapies to treat human immunodeficiency virus type 1 (HIV-1) infection. Doravirine metabolism predominantly occurs via cytochrome P450 3A with &lt;10% of elimination occurring via the renal pathway.

Severe Renal Impairment Has Minimal Impact on Doravirine Pharmacokinetics