Activity of Antimicrobial Combinations against KPC-2-Producing Klebsiella pneumoniae in a Rat Model and Time-Kill Assay | Zendy

Paula Virginia Michelon Toledo | Zendy; Ayrton Alves Aranha | Zendy; Lavinia Nery Villa Stangler Arend | Zendy; Vanessa Bley Ribeiro | Zendy; Alexandre Prehn Zavascki | Zendy; Felipe Francisco Tuon | Zendy

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Activity of Antimicrobial Combinations against KPC-2-Producing Klebsiella pneumoniae in a Rat Model and Time-Kill Assay

Author(s) -

Paula Virginia Michelon Toledo,

Ayrton Alves Aranha,

Lavinia Nery Villa Stangler Arend,

Vanessa Bley Ribeiro,

Alexandre Prehn Zavascki,

Felipe Francisco Tuon

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00323-15

Subject(s) - klebsiella pneumoniae , tigecycline , meropenem , microbiology and biotechnology , polymyxin b , in vivo , antimicrobial , in vitro , biology , antibiotics , medicine , escherichia coli , antibiotic resistance , biochemistry , gene

This study evaluated the efficacy of tigecycline (TIG), polymyxin B (PMB), and meropenem (MER) in 80 rats challenged with Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae infection. A time-kill assay was performed with the same strain. Triple therapy and PMB+TIG were synergistic, promoted 100% survival, and produced negative peritoneal cultures, while MER+TIG showed lower survival and higher culture positivity than other regimens (P = 0.018) and was antagonistic. In vivo and in vitro studies showed that combined regimens, except MER+TIG, were more effective than monotherapies for this KPC-producing strain.

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