Determination of Voriconazole Serum Concentration by Bioassay, a Valid Method for Therapeutic Drug Monitoring for Clinical Laboratories | Zendy

Emilio CendejasBueno | Zendy; Manuel CuencaEstrella | Zendy; Alicia GómezLópez | Zendy

Open Access

Determination of Voriconazole Serum Concentration by Bioassay, a Valid Method for Therapeutic Drug Monitoring for Clinical Laboratories

Author(s) -

Emilio CendejasBueno,

Manuel CuencaEstrella,

Alicia GómezLópez

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00323-13

Subject(s) - bioassay , voriconazole , therapeutic drug monitoring , drug , pharmacology , medicine , serum concentration , chromatography , chemistry , biology , antifungal , dermatology , genetics

We describe here a simple, fast, and reliable bioassay method for therapeutic drug monitoring of voriconazole. Fifty-eight clinical and external quality control samples were evaluated with this microbiological assay, and results were compared with those obtained with a previously validated chromatographic method. A good correlation between both assays was observed. This particular microbiological method was demonstrated to be simple and offers enough precision and accuracy to perform voriconazole therapeutic drug monitoring in laboratories without specialized equipment.

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