Open AccessgyrA and parC Mutations and Associated Quinolone Resistance in Vibrio anguillarum Serotype O2b Strains Isolated from Farmed Atlantic Cod ( Gadus morhua ) in Norway
Author(s) -
D.J. Colquhoun,
L. Aarflot,
C. F. Melvold
Publication year - 2007
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00315-07
Subject(s) - vibrio anguillarum , biology , microbiology and biotechnology , gadus , oxolinic acid , serotype , quinolone , vibrionaceae , vibrio , virology , bacteria , antibiotics , antibiotic resistance , genetics , nalidixic acid , fish <actinopterygii> , fishery
MIC testing ofVibrio anguillarum isolates recovered from diseased farmed Atlantic cod revealed oxolinic acid MICs of ≤0.001, 0.06, and 16 μg ml−1 . SinglegyrA Ser-Ile substitutions were identified at position 83 of the intermediate and resistant strains, while aparC Ser-Leu substitution at position 85 was found only in the resistant strain.