Inhibition ofPlasmodium falciparumGrowth In Vitro and Adhesion to Chondroitin-4-Sulfate by the Heparan Sulfate Mimetic PI-88 and Other Sulfated Oligosaccharides | Zendy

Yvonne Adams | Zendy; Craig Freeman | Zendy; Reinhard SchwartzAlbiez | Zendy; Vito Ferro | Zendy; Christopher R. Parish | Zendy; Katherine T. Andrews | Zendy

Open Access

Inhibition ofPlasmodium falciparumGrowth In Vitro and Adhesion to Chondroitin-4-Sulfate by the Heparan Sulfate Mimetic PI-88 and Other Sulfated Oligosaccharides

Author(s) -

Yvonne Adams,

Craig Freeman,

Reinhard SchwartzAlbiez,

Vito Ferro,

Christopher R. Parish,

Katherine T. Andrews

Publication year - 2006

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00313-06

Subject(s) - plasmodium falciparum , sulfation , in vitro , adhesion , chondroitin sulfate , heparan sulfate , cell adhesion , biochemistry , chemistry , pharmacology , biology , glycosaminoglycan , immunology , malaria , organic chemistry

A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental malaria receptor chondroitin-4-sulfate (CSA). The heparan sulfate mimetic PI-88, currently undergoing phase II anticancer trials, displayed the greatest in vitro antimalarial activity against Plasmodium falciparum (50% inhibitory concentration of 7.4 microM) and demonstrated modest adhesion inhibition to cell surface CSA.

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