Pharmacokinetic Changes during Pregnancy According to Genetic Variants: a Prospective Study in HIV-Infected Patients Receiving Atazanavir-Ritonavir | Zendy

Emanuele Focà | Zendy; Andrea Calcagno | Zendy; Andrea Bonito | Zendy; Jessica Cusato | Zendy; Elisabetta Domenighini | Zendy; Antonio D’Avolio | Zendy; Eugenia Quirós-Roldán | Zendy; L. Trentini | Zendy; Filippo Castelnuovo | Zendy; Giovanni Di Perri | Zendy; Francesco Castelli | Zendy; Stefano Bonora | Zendy

Open Access

Pharmacokinetic Changes during Pregnancy According to Genetic Variants: a Prospective Study in HIV-Infected Patients Receiving Atazanavir-Ritonavir

Author(s) -

Emanuele Focà,

Andrea Calcagno,

Andrea Bonito,

Jessica Cusato,

Elisabetta Domenighini,

Antonio D’Avolio,

Eugenia Quirós-Roldán,

L. Trentini,

Filippo Castelnuovo,

Giovanni Di Perri,

Francesco Castelli,

Stefano Bonora

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00309-18

Subject(s) - atazanavir , ritonavir , pharmacokinetics , medicine , pregnancy , human immunodeficiency virus (hiv) , pharmacology , prospective cohort study , virology , viral load , antiretroviral therapy , biology , genetics

Atazanavir-ritonavir concentrations change over time during pregnancy in HIV-positive patients; the impact of genetic variants is unknown. Twenty patients were enrolled in this study; plasma and intracellular concentrations of antiretrovirals were measured, in addition to single-nucleotide polymorphisms in transport-related genes. Linear logistic regression showed that genetic variants in organic-anion-transporter-1B1- and pregnane-X-receptor-encoding genes affected third-trimester atazanavir exposure. In this prospective study, genetic variants partially explained the observed interpatient variability in third-trimester exposure to antiretrovirals.

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