Measurement of Voriconazole Activity against Candida albicans , C. glabrata , and C. parapsilosis Isolates Using Time-Kill Methods Validated by High-Performance Liquid Chromatography | Zendy

Yanjun Li | Zendy; M. Hong Nguyen | Zendy; Hartmut Derendorf | Zendy; Shaoji Cheng | Zendy; Cornelius J. Clancy | Zendy

Open Access

Measurement of Voriconazole Activity against Candida albicans , C. glabrata , and C. parapsilosis Isolates Using Time-Kill Methods Validated by High-Performance Liquid Chromatography

Author(s) -

Yanjun Li,

M. Hong Nguyen,

Hartmut Derendorf,

Shaoji Cheng,

Cornelius J. Clancy

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00308-07

Subject(s) - voriconazole , candida albicans , high performance liquid chromatography , candida parapsilosis , candida glabrata , microbiology and biotechnology , corpus albicans , biology , chromatography , chemistry , antifungal

We developed a high-performance liquid chromatography (HPLC) assay to validate time-kill and postantifungal-effect (PAFE) experiments for voriconazole againstCandida albicans ,Candida glabrata , andCandida parapsilosis isolates. Voriconazole exerted prolonged fungistatic activity but no PAFE at concentrations achievable in human sera. HPLC confirmed that experiments were conducted at the desired steady-state voriconazole concentrations.

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