Antibiotic-Resistant Klebsiella pneumoniae and Escherichia coli High-Risk Clones and an IncFII k Mosaic Plasmid Hosting Tn 1 ( bla TEM-4 ) in Isolates from 1990 to 2004 | Zendy

Irene Rodríguez | Zendy; Ângela Novais | Zendy; Felipe Lira | Zendy; Aránzazu Valverde | Zendy; Tânia Curião | Zendy; José Luis Martínez | Zendy; Fernando Baquero | Zendy; Rafael Cantón | Zendy; Teresa M. Coque | Zendy

Open Access

Antibiotic-Resistant Klebsiella pneumoniae and Escherichia coli High-Risk Clones and an IncFII _k Mosaic Plasmid Hosting Tn 1 ( bla _TEM-4 ) in Isolates from 1990 to 2004

Author(s) -

Irene Rodríguez,

Ângela Novais,

Felipe Lira,

Aránzazu Valverde,

Tânia Curião,

José Luis Martínez,

Fernando Baquero,

Rafael Cantón,

Teresa M. Coque

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00296-15

Subject(s) - klebsiella pneumoniae , plasmid , escherichia coli , microbiology and biotechnology , virology , enterobacteriaceae , biology , antibiotics , klebsiella , dna , gene , genetics

We describe the genetic background of bla(TEM-4) and the complete sequence of pRYC11::bla(TEM-4), a mosaic plasmid that is highly similar to pKpQIL-like variants, predominant among TEM-4 producers in a Spanish hospital (1990 to 2004), which belong to Klebsiella pneumoniae and Escherichia coli high-risk clones responsible for the current spread of different antibiotic resistance genes. Predominant populations of plasmids and host adapted clonal lineages seem to have greatly contributed to the spread of resistance to extended-spectrum cephalosporins.

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