Open AccessDifferential Gene Expression in Response to Exposure to Antimycobacterial Agents and Other Stress Conditions among Seven Mycobacterium tuberculosis whiB- Like Genes
Author(s) -
Deborah E. Geiman,
Tirumalai R. Raghunand,
Nisheeth Agarwal,
William R. Bishai
Publication year - 2006
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00295-06
Subject(s) - antimycobacterial , mycobacterium tuberculosis , biology , gene , tuberculosis , gene expression , encode , genetics , mycobacterium , transcription (linguistics) , microbiology and biotechnology , bacteria , medicine , pathology , linguistics , philosophy
The sevenMycobacterium tuberculosis whiB -like genes encode small proteins postulated to be transcriptional regulators. A systematic real-time reverse transcription-PCR analysis following exposure to antibiotics and a variety of growth and in vitro stress conditions indicates differential, and in some cases dramatic, transcription modulations for the differentM. tuberculosis whiB family members. This information together with biochemical analyses of thewhiB1 towhiB7 gene products will be important for understanding the biology of this novel family of proteins in mycobacteria and related actinomycetes.