Emergence of Extensively Drug-Resistant Proteus mirabilis Harboring a Conjugative NDM-1 Plasmid and a Novel Salmonella Genomic Island 1 Variant, SGI1-Z | Zendy

Shangshang Qin | Zendy; Hui Qi | Zendy; Qijing Zhang | Zendy; Di Zhao | Zendy; Zhenzhen Liu | Zendy; Hao Tian | Zendy; Lijuan Xu | Zendy; Hui Xu | Zendy; Mengmeng Zhou | Zendy; Xianju Feng | Zendy; HongMin Liu | Zendy

Open Access

Emergence of Extensively Drug-Resistant Proteus mirabilis Harboring a Conjugative NDM-1 Plasmid and a Novel Salmonella Genomic Island 1 Variant, SGI1-Z

Author(s) -

Shangshang Qin,

Hui Qi,

Qijing Zhang,

Di Zhao,

Zhenzhen Liu,

Hao Tian,

Lijuan Xu,

Hui Xu,

Mengmeng Zhou,

Xianju Feng,

HongMin Liu

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00292-15

Subject(s) - proteus mirabilis , tigecycline , genomic island , biology , microbiology and biotechnology , tetracycline , plasmid , colistin , salmonella , drug resistance , aztreonam , genetics , virology , staphylococcus aureus , bacteria , antibiotics , antibiotic resistance , dna , imipenem

Acquisition of blaNDM-1 in bacterial species, such as Proteus mirabilis that is intrinsically resistant to tetracycline, tigecycline and colistin, will make clinical treatment extremely difficult. Here, we characterized an NDM-1-producing clinical isolate of P. mirabilis (PM58) that displayed an extensively drug-resistant (XDR) phenotype, susceptible only to aztreonam. Molecular analysis revealed that PM58 harbored both a conjugative NDM-1 plasmid and a novel Salmonella genomic island 1 variant on chromosome.

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