Characterizing the Effects of Caspofungin on Candida albicans , Candida parapsilosis , and Candida glabrata Isolates by Simultaneous Time-Kill and Postantifungal-Effect Experiments | Zendy

Cornelius J. Clancy | Zendy; Hong Huang | Zendy; Shaoji Cheng | Zendy; Hartmut Derendorf | Zendy; M. Hong Nguyen | Zendy

Open Access

Characterizing the Effects of Caspofungin on Candida albicans , Candida parapsilosis , and Candida glabrata Isolates by Simultaneous Time-Kill and Postantifungal-Effect Experiments

Author(s) -

Cornelius J. Clancy,

Hong Huang,

Shaoji Cheng,

Hartmut Derendorf,

M. Hong Nguyen

Publication year - 2006

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00291-06

Subject(s) - caspofungin , candida parapsilosis , candida glabrata , candida albicans , microbiology and biotechnology , biology , fungi imperfecti , echinocandins , fungemia , fluconazole , antifungal

We measured time-kills and postantifungal effects (PAFEs) of caspofungin against Candida albicans, C. parapsilosis, and C. glabrata isolates. One-hour exposure to caspofungin during PAFE experiments accounted for the majority of killing during time-kill experiments. Regrowth of all isolates was inhibited for at least 24 h following drug washout.

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