Efficacy of Ceftaroline Fosamil against Escherichia coli and Klebsiella pneumoniae Strains in a Rabbit Meningitis Model | Zendy

A. Stucki | Zendy; F. Acosta | Zendy; M. Cottagnoud | Zendy; P. Cottagnoud | Zendy

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Efficacy of Ceftaroline Fosamil against Escherichia coli and Klebsiella pneumoniae Strains in a Rabbit Meningitis Model

Author(s) -

A. Stucki,

F. Acosta,

M. Cottagnoud,

P. Cottagnoud

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00285-13

Subject(s) - klebsiella pneumoniae , microbiology and biotechnology , cefepime , escherichia coli , cephalosporin , meningitis , biology , antibiotics , medicine , antibiotic resistance , biochemistry , imipenem , gene , psychiatry

In this study, the efficacy of ceftaroline fosamil was compared with that of cefepime in an experimental rabbit meningitis model against two Gram-negative strains (Escherichia coli QK-9 andKlebsiella pneumoniae 1173687). The penetration of ceftaroline into inflamed and uninflamed meninges was also investigated. Both regimens were bactericidal, but ceftaroline fosamil was significantly superior to cefepime againstK. pneumoniae andE. coli in this experimental rabbit meningitis model (P < 0.0007 againstK. pneumoniae andP < 0.0016 againstE. coli ). The penetration of ceftaroline was approximately 15% into inflamed meninges and approximately 3% into uninflamed meninges.

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