In Vitro Activity of Retapamulin against Staphylococcus aureus Resistant to Various Antimicrobial Agents | Zendy

Louis D. Saravolatz | Zendy; Joan Pawlak | Zendy; Stephanie N. Saravolatz | Zendy; Leonard B. Johnson | Zendy

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In Vitro Activity of Retapamulin against Staphylococcus aureus Resistant to Various Antimicrobial Agents

Author(s) -

Louis D. Saravolatz,

Joan Pawlak,

Stephanie N. Saravolatz,

Leonard B. Johnson

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00282-13

Subject(s) - mupirocin , microbiology and biotechnology , staphylococcus aureus , broth microdilution , methicillin resistant staphylococcus aureus , antimicrobial , linezolid , vancomycin , daptomycin , fusidic acid , medicine , biology , minimum inhibitory concentration , bacteria , genetics

Retapamulin and six other antimicrobial agents were evaluated against 155 methicillin-resistant Staphylococcus aureus (MRSA) isolates, including strains resistant to vancomycin, linezolid, daptomycin, and mupirocin by microdilution tests. Time-kill assays were performed against representative MRSA, vancomycin-intermediate S. aureus (VISA), and vancomycin-resistant S. aureus (VRSA) isolates. Retapamulin and mupirocin demonstrated MIC 90 s of 0.12 μg/ml and 8 μg/ml, respectively, with resistance seen in 2.6% and 10% of isolates, respectively. Retapamulin maintained good activity against 94% (15/16) of mupirocin-resistant isolates.

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