Oritavancin Activity Tested against Molecularly Characterized Staphylococci and Enterococci Displaying Elevated Linezolid MIC Results | Zendy

Rodrigo E. Mendes | Zendy; David J. Farrell | Zendy; Hélio S. Sader | Zendy; Robert K. Flamm | Zendy; Ronald N. Jones | Zendy

Open Access

Oritavancin Activity Tested against Molecularly Characterized Staphylococci and Enterococci Displaying Elevated Linezolid MIC Results

Author(s) -

Rodrigo E. Mendes,

David J. Farrell,

Hélio S. Sader,

Robert K. Flamm,

Ronald N. Jones

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00281-16

Subject(s) - linezolid , microbiology and biotechnology , enterococcus , staphylococcus aureus , chemistry , antibiotics , vancomycin , biology , bacteria , genetics

Oritavancin (MIC50/90, 0.03/0.06 to 0.12 μg/ml) had potent activity against linezolid-resistant staphylococci, as well as Enterococcus faecalis and Enterococcus faecium (oritavancin MIC50/90, 0.015/0.12 μg/ml against both species). All linezolid-resistant isolates were inhibited by oritavancin at ≤0.12 μg/ml. These results confirmed the absence of cross-resistance between linezolid and oritavancin in staphylococci and enterococci.

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