Open AccessPharmacokinetics and Comprehensive Analysis of the Tissue Distribution of Eravacycline in Rabbits
Author(s) -
Vidmantas Petraitis,
Rūta Petraitienė,
Bo Bo Win Maung,
Farehin Khan,
Ieva Alisauskaite,
Melanie Olesky,
Joseph Newman,
Abdul Mutlib,
Xiaoyun Niu,
Michael J. Satlin,
Ravi Shankar Prasad Singh,
H. Derendorf,
Thomas J. Walsh
Publication year - 2018
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00275-18
Subject(s) - pharmacokinetics , pharmacology , dosing , antibiotics , distribution (mathematics) , microbiology and biotechnology , medicine , biology , mathematical analysis , mathematics
Eravacycline (7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline or TP-434) is a novel, fully synthetic broad-spectrum fluorocycline with potent activity against Gram-positive bacteria, anaerobes, and multidrug-resistantEnterobacteriaceae . We characterized the plasma pharmacokinetics of eravacycline and conducted a comprehensive analysis of the eravacycline tissue distribution in rabbits after multiple-day dosing.
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