Activity of Tedizolid (TR-700) against Well-Characterized Methicillin-Resistant Staphylococcus aureus Strains of Diverse Epidemiological Origins | Zendy

Kenneth S. Thomson | Zendy; Richard V. Goering | Zendy

Open Access

Activity of Tedizolid (TR-700) against Well-Characterized Methicillin-Resistant Staphylococcus aureus Strains of Diverse Epidemiological Origins

Author(s) -

Kenneth S. Thomson,

Richard V. Goering

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00274-13

Subject(s) - tigecycline , daptomycin , linezolid , staphylococcus aureus , microbiology and biotechnology , methicillin resistant staphylococcus aureus , antibiotics , vancomycin , medicine , biology , bacteria , genetics

Thein vitro activities of tedizolid and 10 antistaphylococcal agents were compared against 111 methicillin-resistantStaphylococcus aureus (MRSA) strains from 14 epidemiologically characterized groups. Tedizolid, tigecycline, and daptomycin were the most potent agents, with tedizolid 4-fold more potent than linezolid. Tedizolid, linezolid, and vancomycin were unaffected by epidemiological types. Tigecycline and daptomycin had reduced potency against ST80-MRSA-IV and ST239-MRSA-III, respectively. Overall, tedizolid was highly potent against all MRSA strain types, including those resistant to other classes of drugs.

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