In Vivo Reversion to the Wild-Type β-Lactam Resistance Phenotype Mediated by a Plasmid CarryingampRandqnrA1inEnterobacter cloacae | Zendy

Juan José GonzálezLópez | Zendy; Montserrat Sabaté | Zendy; S. Lavilla | Zendy; Nieves Larrosa | Zendy; Rosa Bartolomé | Zendy; Guillem Prats | Zendy

Open Access

In Vivo Reversion to the Wild-Type β-Lactam Resistance Phenotype Mediated by a Plasmid CarryingampRandqnrA1inEnterobacter cloacae

Author(s) -

Juan José GonzálezLópez,

Montserrat Sabaté,

S. Lavilla,

Nieves Larrosa,

Rosa Bartolomé,

Guillem Prats

Publication year - 2006

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00273-06

Subject(s) - enterobacter cloacae , reversion , plasmid , biology , microbiology and biotechnology , genetics , enterobacteriaceae , phenotype , enterobacteriaceae infections , wild type , gene , mutant , escherichia coli

Resistance to beta-lactams and quinolones in two isogenic Enterobacter cloacae isolates was studied. One was susceptible to cefoxitin and amoxicillin-clavulanate. The other one showed its natural beta-lactam resistance pattern. Both isolates had a nonfunctional AmpR regulator. However, within the second one, the presence of a plasmid carrying ampR and qnrA1 allowed reversion to the wild-type beta-lactam resistance phenotype and decreased susceptibility to fluoroquinolones.

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