Open AccessIncidence and Antimicrobial Susceptibility of Escherichia coli and Klebsiella pneumoniae with Extended-Spectrum β-Lactamases in Community- and Hospital-Associated Intra-Abdominal Infections in Europe: Results of the 2008 Study for Monitoring Antimicrobial Resistance Trends (SMART)
Author(s) -
Stephen Hawser,
Samuel K. Bouchillon,
Daryl J. Hoban,
Robert E. Badal,
Rafael Cantón,
Fernando Baquero
Publication year - 2010
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00265-10
Subject(s) - klebsiella pneumoniae , microbiology and biotechnology , escherichia coli , antimicrobial , incidence (geometry) , biology , antibiotics , beta lactamase , medicine , biochemistry , physics , optics , gene
From 2002 to 2008, there was a significant increase in extended-spectrum beta-lactamase (ESBL)-positiveEscherichia coli isolates in European intra-abdominal infections, from 4.3% in 2002 to 11.8% in 2008 (P < 0.001), but not for ESBL-positiveKlebsiella pneumoniae isolates (16.4% to 17.9% [P > 0.05]). Hospital-associated isolates were more common than community-associated isolates, at 14.0% versus 6.5%, respectively, forE. coli (P < 0.001) and 20.9% versus 5.3%, respectively, forK. pneumoniae (P < 0.01). Carbapenems were consistently the most active drugs tested.
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