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From 2002 to 2008, there was a significant increase in extended-spectrum beta-lactamase (ESBL)-positiveEscherichia coli isolates in European intra-abdominal infections, from 4.3% in 2002 to 11.8% in 2008 (P &lt; 0.001), but not for ESBL-positiveKlebsiella pneumoniae isolates (16.4% to 17.9% [P &gt; 0.05]). Hospital-associated isolates were more common than community-associated isolates, at 14.0% versus 6.5%, respectively, forE. coli (P &lt; 0.001) and 20.9% versus 5.3%, respectively, forK. pneumoniae (P &lt; 0.01). Carbapenems were consistently the most active drugs tested.

antimicrobial agents and chemotherapy

Incidence and Antimicrobial Susceptibility of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> with Extended-Spectrum β-Lactamases in Community- and Hospital-Associated Intra-Abdominal Infections in Europe: Results of the 2008 Study for Monitoring Antimicrobial Resistance Trends (SMART)

Incidence and Antimicrobial Susceptibility of Escherichia coli and Klebsiella pneumoniae with Extended-Spectrum β-Lactamases in Community- and Hospital-Associated Intra-Abdominal Infections in Europe: Results of the 2008 Study for Monitoring Antimicrobial Resistance Trends (SMART)