Open AccessIntrinsic Macrolide Resistance of the Mycobacterium tuberculosis Complex Is Inducible
Author(s) -
Nadya Andini,
Kevin A. Nash
Publication year - 2006
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00264-06
Subject(s) - ketolide , mycobacterium tuberculosis , clarithromycin , microbiology and biotechnology , tuberculosis , biology , antibacterial agent , antibiotics , medicine , pathology
Mycobacterium tuberculosis is intrinsically resistant to macrolides, a characteristic associated with expression of the erm(37) gene. This intrinsic resistance was found to be inducible with clarithromycin and the ketolide HMR3004. Furthermore, underlying the phenotypic induction was an increase in erm(37) mRNA levels.
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