Analysis of Anti-Clostridium difficile Activity of Thuricin CD, Vancomycin, Metronidazole, Ramoplanin, and Actagardine, both Singly and in Paired Combinations | Zendy

Harsh Mathur | Zendy; Paula M. O’Connor | Zendy; Colin Hill | Zendy; Paul D. Cotter | Zendy; R. Paul Ross | Zendy

Open Access

Analysis of Anti-Clostridium difficile Activity of Thuricin CD, Vancomycin, Metronidazole, Ramoplanin, and Actagardine, both Singly and in Paired Combinations

Author(s) -

Harsh Mathur,

Paula M. O’Connor,

Colin Hill,

Paul D. Cotter,

R. Paul Ross

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00261-13

Subject(s) - metronidazole , clostridium difficile , vancomycin , microbiology and biotechnology , clostridium , biology , antibiotics , chemistry , bacteria , staphylococcus aureus , genetics

Due to the ongoing problem of recurrence ofClostridium difficile -associated diarrhea following antibiotic treatment, there is an urgent need for alternative treatment options. We assessed the MICs of five antimicrobials singly and in combinations against a range ofC. difficile clinical isolates. Ramoplanin-actagardine combinations were particularly effective, with partial synergistic/additive effects observed against 61.5% ofC. difficile strains tested.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research