Resistance Genes Underlying the LS A Phenotype of Staphylococcal Isolates from France | Zendy

Sophie Tessé | Zendy; François Trueba | Zendy; Nicolás Berthet | Zendy; Chloé Hot | Zendy; O. Chesneau | Zendy

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Resistance Genes Underlying the LS _A Phenotype of Staphylococcal Isolates from France

Author(s) -

Sophie Tessé,

François Trueba,

Nicolás Berthet,

Chloé Hot,

O. Chesneau

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00259-13

Subject(s) - lincosamides , lincomycin , gene , genetics , phenotype , biology , mobile genetic elements , microbiology and biotechnology , antibiotic resistance , bacteria , antibiotics , plasmid

There exist numerous genes disseminated by mobile elements that can confer cross-resistance to lincosamides and streptogramin A compounds in staphylococci. This study investigated the nature and means of dissemination of genes responsible for LS A resistance among 24 French clinical isolates screened for reduced susceptibility to lincomycin. The vga (A) v gene was found to be the most prevalent determinant of LS A resistance, while Tn 5406 appeared to be its exclusive gene support.

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