Chromosomal Integration and Location on IncT Plasmids of the bla CTX-M-2 Gene in Proteus mirabilis Clinical Isolates | Zendy

Sohei Harada | Zendy; Yoshikazu Ishii | Zendy; Tomoo Saga | Zendy; Yuichi Kouyama | Zendy; Kazuhiro Tateda | Zendy; Keizo Yamaguchi | Zendy

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Chromosomal Integration and Location on IncT Plasmids of the bla _CTX-M-2 Gene in Proteus mirabilis Clinical Isolates

Author(s) -

Sohei Harada,

Yoshikazu Ishii,

Tomoo Saga,

Yuichi Kouyama,

Kazuhiro Tateda,

Keizo Yamaguchi

Publication year - 2011

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00258-11

Subject(s) - proteus mirabilis , plasmid , biology , chromosome , gene , proteus , genetics , microbiology and biotechnology , escherichia coli

Analysis of five CTX-M-2-producingProteus mirabilis isolates in Japan demonstrated thatbla CTX-M-2 was located on the chromosome in four isolates and on IncT plasmids in three isolates, including two isolates that also carried the gene on the chromosome. In all four isolates with chromosomalbla CTX-M-2 , ISEcp1 was responsible for the integration of the gene into the chromosome. Three different sites in theP. mirabilis genomic sequence were utilized as integration sites.

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