Body Surface Area-Based Dosing Regimen of Caspofungin in Children: a Population Pharmacokinetics Confirmatory Study | Zendy

XinMei Yang | Zendy; Stéphanie Leroux | Zendy; Thomas Storme | Zendy; Daolun Zhang | Zendy; Tiphaine Adam de Beaumais | Zendy; HaiYan Shi | Zendy; Yilei Yang | Zendy; XiaoLing Wang | Zendy; Wei Zhao | Zendy; Evelyne JacqzAigrain | Zendy

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Body Surface Area-Based Dosing Regimen of Caspofungin in Children: a Population Pharmacokinetics Confirmatory Study

Author(s) -

XinMei Yang,

Stéphanie Leroux,

Thomas Storme,

Daolun Zhang,

Tiphaine Adam de Beaumais,

HaiYan Shi,

Yilei Yang,

XiaoLing Wang,

Wei Zhao,

Evelyne JacqzAigrain

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00248-19

Subject(s) - caspofungin , pharmacokinetics , dosing , body surface area , regimen , population pharmacokinetics , population , medicine , pharmacology , antifungal , environmental health , voriconazole , dermatology

We evaluated the population pharmacokinetics of caspofungin in children (2 to 12 years of age). The real-world data from 48 children were best fit by a two-compartment model with first-order elimination. Subsequent covariate analysis demonstrated that body surface area had a significant correlation with caspofungin pharmacokinetics, compared to body weight. The population pharmacokinetics of caspofungin confirmed that adjustment of caspofungin dosage based on body surface area is most appropriate for pediatric use.

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