Open AccessCharacterization of TolC Efflux Pump Proteins from Pasteurella multocida
Author(s) -
Tamas Hatfaludi,
Keith Al-Hasani,
Michelle Anne Dunstone,
John D. Boyce,
Ben Adler
Publication year - 2008
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00245-08
Subject(s) - pasteurella multocida , efflux , microbiology and biotechnology , mutant , ceftazidime , acridine orange , chemistry , antibiotics , antibacterial agent , biology , bacteria , biochemistry , genetics , pseudomonas aeruginosa , apoptosis , gene
Two TolC homologs, PM0527 and PM1980, were identified forPasteurella multocida . A pm0527 mutant displayed increased susceptibility to a range of chemicals, including rifampin (512-fold) and acridine orange (128-fold). A pm1980 mutant showed increased susceptibility to rifampin, ceftazidime, and vancomycin.