Genomic and Functional Analysis of Emerging Virulent and Multidrug-Resistant Escherichia coli Lineage Sequence Type 648 | Zendy

Katharina Schaufler | Zendy; Torsten Semmler | Zendy; Lothar H. Wieler | Zendy; Darren J. Trott | Zendy; Johann Pitout | Zendy; Gisele Peirano | Zendy; Jonas Bonnedahl | Zendy; Monika Dolejská | Zendy; Ivan Literák | Zendy; Stephan Fuchs | Zendy; Niyaz Ahmed | Zendy; Mirjam Grobbel | Zendy; Cármen Torres | Zendy; Alan McNally | Zendy; Derek Pickard | Zendy; Christa Ewers | Zendy; Nicholas J. Croucher | Zendy; Jukka Corander | Zendy; Sebastian Guenther | Zendy

Open Access

Genomic and Functional Analysis of Emerging Virulent and Multidrug-Resistant Escherichia coli Lineage Sequence Type 648

Author(s) -

Katharina Schaufler,

Torsten Semmler,

Lothar H. Wieler,

Darren J. Trott,

Johann Pitout,

Gisele Peirano,

Jonas Bonnedahl,

Monika Dolejská,

Ivan Literák,

Stephan Fuchs,

Niyaz Ahmed,

Mirjam Grobbel,

Cármen Torres,

Alan McNally,

Derek Pickard,

Christa Ewers,

Nicholas J. Croucher,

Jukka Corander,

Sebastian Guenther

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00243-19

Subject(s) - biology , virulence , lineage (genetic) , multiple drug resistance , escherichia coli , sequence (biology) , genetics , microbiology and biotechnology , sequence analysis , drug resistance , gene

The pathogenic extended-spectrum-beta-lactamase (ESBL)-producingEscherichia coli lineage ST648 is increasingly reported from multiple origins. Our study of a large and global ST648 collection from various hosts (87 whole-genome sequences) combining core and accessory genomics with functional analyses andin vivo experiments suggests that ST648 is a nascent and generalist lineage, lacking clear phylogeographic and host association signals.

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