Transient Loss of High-Level Mupirocin Resistance in Staphylococcus aureus Due to MupA Polymorphism | Zendy

Daniel G. Driscoll | Zendy; Casey L. Young | Zendy; Urs A. Ochsner | Zendy

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Transient Loss of High-Level Mupirocin Resistance in Staphylococcus aureus Due to MupA Polymorphism

Author(s) -

Daniel G. Driscoll,

Casey L. Young,

Urs A. Ochsner

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00241-07

Subject(s) - mupirocin , staphylococcus aureus , reversion , frameshift mutation , biology , microbiology and biotechnology , allele , genetics , gene , methicillin resistant staphylococcus aureus , mutation , bacteria , phenotype

Spontaneous loss of MupA-mediated high-level mupirocin resistance was observed inStaphylococcus aureus , although the isolate gave a PCR-positive test result formupA . Sequencing of themupA gene identified a single base-pair deletion that resulted in a frameshift mutation and loss of functional protein. Reversion to the wild-type allele and restoration of high-level resistance occurred with high frequency (>10−6 ), indicating the transient nature of MupA polymorphism.

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