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Molecular Testing of Serial Blood Specimens from Patients with Early Lyme Disease during Treatment Reveals Changing Coinfection with Mixtures of Borrelia burgdorferi Genotypes
Author(s) -
Michael R. Mosel,
Heather E. Carolan,
Alison W. Rebman,
Steven Castro,
Christian Massire,
David J. Ecker,
Mark J. Soloski,
John N. Aucott,
Mark W. Eshoo
Publication year - 2019
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00237-19
Subject(s) - lyme disease , borrelia burgdorferi , coinfection , borrelia , spirochaetaceae , genotype , virology , biology , medicine , microbiology and biotechnology , immunology , human immunodeficiency virus (hiv) , antibody , genetics , gene
Borrelia burgdorferi is the etiological agent of Lyme disease. In the current study, we used direct-detection PCR and electrospray ionization mass spectrometry to monitor and genotypeB. burgdorferi isolates from serially collected whole-blood specimens from patients clinically diagnosed with early Lyme disease before and during 21 days of antibiotic therapy.

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