Acquisition of Broad-Spectrum Cephalosporin Resistance Leading to Colistin Resistance in Klebsiella pneumoniae | Zendy

Aurélie Jayol | Zendy; Patrice Nordmann | Zendy; Marine Desroches | Zendy; JeanWinoc Decousser | Zendy; Laurent Poirel | Zendy

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Acquisition of Broad-Spectrum Cephalosporin Resistance Leading to Colistin Resistance in Klebsiella pneumoniae

Author(s) -

Aurélie Jayol,

Patrice Nordmann,

Marine Desroches,

JeanWinoc Decousser,

Laurent Poirel

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00237-16

Subject(s) - klebsiella pneumoniae , colistin , cephalosporin , cefotaxime , microbiology and biotechnology , transposition (logic) , biology , mcr 1 , broad spectrum , enterobacteriaceae , insertion sequence , gene , antibiotics , genetics , escherichia coli , genome , chemistry , transposable element , linguistics , philosophy , combinatorial chemistry

An extended-spectrum β-lactamase (ESBL)-producing and colistin-resistantKlebsiella pneumoniae clinical isolate was recovered from a patient who was treated with cefotaxime. This isolate harbored abla CTX-M-15 ESBL gene that was associated with an ISEcp1 insertion sequence. Transposition of that tandem occurred within the chromosomalmgrB gene, leading to inactivation of themgrB gene and consequently to acquired resistance to colistin. We showed here a coselection of colistin resistance as a result of a broad-spectrum cephalosporin selective pressure.

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