Evaluation of the Bactericidal Activity of Plazomicin and Comparators against Multidrug-Resistant Enterobacteriaceae | Zendy

Mary Thwaites | Zendy; Devon Hall | Zendy; Dean L. Shinabarger | Zendy; Alisa W. Serio | Zendy; Kevin M. Krause | Zendy; Andrea Marra | Zendy; Chris M. Pillar | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Evaluation of the Bactericidal Activity of Plazomicin and Comparators against Multidrug-Resistant Enterobacteriaceae

Author(s) -

Mary Thwaites,

Devon Hall,

Dean L. Shinabarger,

Alisa W. Serio,

Kevin M. Krause,

Andrea Marra,

Chris M. Pillar

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00236-18

Subject(s) - enterobacteriaceae , aminoglycoside , colistin , microbiology and biotechnology , klebsiella pneumoniae , multiple drug resistance , enterobacter , biology , escherichia coli , antibiotics , biochemistry , gene

The next-generation aminoglycoside plazomicin, in development for infections due to multidrug-resistant (MDR) Enterobacteriaceae , was evaluated alongside comparators for bactericidal activity in minimum bactericidal concentration (MBC) and time-kill (TK) assays against MDR Enterobacteriaceae isolates with characterized aminoglycoside and β-lactam resistance mechanisms. Overall, plazomicin and colistin were the most potent, with plazomicin demonstrating an MBC 50/90 of 0.5/4 μg/ml and sustained 3-log 10 kill against MDR Escherichia coli , Klebsiella pneumoniae , and Enterobacter spp.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research