NDM-1-Producing Klebsiella pneumoniae Resistant to Colistin in a French Community Patient without History of Foreign Travel | Zendy

Corinne Arpin | Zendy; Patrick Noury | Zendy; Delphine Boraud | Zendy; Laure Coulange | Zendy; Alain Manetti | Zendy; Catherine André | Zendy; Fatima M’Zali | Zendy; Claudine Quentin | Zendy

Open Access

NDM-1-Producing Klebsiella pneumoniae Resistant to Colistin in a French Community Patient without History of Foreign Travel

Author(s) -

Corinne Arpin,

Patrick Noury,

Delphine Boraud,

Laure Coulange,

Alain Manetti,

Catherine André,

Fatima M’Zali,

Claudine Quentin

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00230-12

Subject(s) - colistin , klebsiella pneumoniae , microbiology and biotechnology , antibiotics , strain (injury) , klebsiella infections , plasmid , biology , klebsiella , virology , medicine , escherichia coli , gene , genetics

A carbapenem-resistant Klebsiella pneumoniae strain, Kp5196, was responsible for an uncomplicated cystitis in a patient living at home and without history of foreign travel. This isolate produced the metallocarbapenemase NDM-1 and was resistant to all antibiotics except tetracyclines and colistin. The K. pneumoniae strain belonged to sequence type ST15, and bla(NDM-1) was carried by a nontypeable conjugative plasmid. Two months later, a similar ST15 isolate, Kp5241, was present in the patient but was additionally colistin resistant.

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