Molecular Confirmation of the Linkage between the Rhizopus oryzae CYP51A Gene Coding Region and Its Intrinsic Voriconazole and Fluconazole Resistance | Zendy

Daiana Macedo | Zendy; Florencia Leonardelli | Zendy; Catiana Dudiuk | Zendy; Laura Theill | Zendy; Matías S. Cabeza | Zendy; Soledad Gamarra | Zendy; Guillermo GarcíaEffrón | Zendy

Open Access

Molecular Confirmation of the Linkage between the Rhizopus oryzae CYP51A Gene Coding Region and Its Intrinsic Voriconazole and Fluconazole Resistance

Author(s) -

Daiana Macedo,

Florencia Leonardelli,

Catiana Dudiuk,

Laura Theill,

Matías S. Cabeza,

Soledad Gamarra,

Guillermo GarcíaEffrón

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00224-18

Subject(s) - voriconazole , rhizopus oryzae , gene , genetics , fluconazole , biology , microbiology and biotechnology , antifungal , biochemistry , fermentation

Rhizopus oryzae is the most prevalent causative agent of mucormycosis, an increasingly reported opportunistic fungal infection. These Mucorales are intrinsically resistant toCandida - andAspergillus -active antifungal azole drugs, such as fluconazole (FLC) and voriconazole, respectively.

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