Novel Streptomycin Resistance Gene from Mycobacterium fortuitum | Zendy

Santiago RamónGarcía | Zendy; Isabel Otal | Zendy; Carlos Martı́n | Zendy; R Gómez-Lus | Zendy; José A. Aı́nsa | Zendy

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Novel Streptomycin Resistance Gene from Mycobacterium fortuitum

Author(s) -

Santiago RamónGarcía,

Isabel Otal,

Carlos Martı́n,

R Gómez-Lus,

José A. Aı́nsa

Publication year - 2006

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00223-06

Subject(s) - streptomycin , mycobacterium fortuitum , streptomyces griseus , microbiology and biotechnology , plasmid , biology , aminoglycoside , gene , streptomyces , phosphotransferase , mycobacterium , antibiotics , genetics , bacteria

We have isolated the aph(3")-Ic gene, encoding an aminoglycoside 3"-O-phosphotransferase [APH(3")-Ic], from a genomic library of an environmental Mycobacterium fortuitum strain, selecting for streptomycin resistance. APH(3")-Ic phosphorylates and inactivates streptomycin. Similar genes have been described in Streptomyces griseus and plasmid RSF1010. It is also present in some M. fortuitum clinical isolates.

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