Emergence of Extensively Drug-Resistant Haemophilus parainfluenzae in Switzerland | Zendy

Regula Tinguely | Zendy; Salomé N. Seiffert | Zendy; Hansjakob Furrer | Zendy; Vincent Perreten | Zendy; Sara Droz | Zendy; Andrea Endimiani | Zendy

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Emergence of Extensively Drug-Resistant Haemophilus parainfluenzae in Switzerland

Author(s) -

Regula Tinguely,

Salomé N. Seiffert,

Hansjakob Furrer,

Vincent Perreten,

Sara Droz,

Andrea Endimiani

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00221-13

Subject(s) - haemophilus parainfluenzae , microbiology and biotechnology , cefepime , cefuroxime , ciprofloxacin , cefotaxime , meropenem , nalidixic acid , biology , virology , azithromycin , ampicillin , haemophilus , antibacterial agent , amoxicillin , haemophilus influenzae , antibiotics , imipenem , antibiotic resistance , bacteria , genetics

Two homosexual men were colonized in the urethra with Haemophilus parainfluenzae nonsusceptible to ampicillin (MIC, 8 μg/ml), amoxicillin-clavulanate (MIC, 4 μg/ml), cefotaxime (MIC, 1.5 μg/ml), cefepime (MIC, 3 μg/ml), meropenem (MIC, 0.5 μg/ml), cefuroxime, azithromycin, ciprofloxacin, tetracycline, and chloramphenicol (all MICs, ≥ 32 μg/ml). Repetitive extragenic palindromic PCR (rep-PCR) showed that the strains were indistinguishable. The isolates had amino acid substitutions in PBP3, L4, GyrA, and ParC and possessed Mef(A), Tet(M), and CatS resistance mechanisms. This is the first report of extensively drug-resistant (XDR) H. parainfluenzae.

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