The Phenolic Diterpene Totarol Inhibits Multidrug Efflux Pump Activity in Staphylococcus aureus | Zendy

Eileen Smith | Zendy; Glenn W. Kaatz | Zendy; Susan M. Seo | Zendy; Neale Wareham | Zendy; Elizabeth M. Williamson | Zendy; Simon Gibbons | Zendy

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The Phenolic Diterpene Totarol Inhibits Multidrug Efflux Pump Activity in Staphylococcus aureus

Author(s) -

Eileen Smith,

Glenn W. Kaatz,

Susan M. Seo,

Neale Wareham,

Elizabeth M. Williamson,

Simon Gibbons

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00216-07

Subject(s) - efflux , staphylococcus aureus , antimicrobial , chemistry , diterpene , microbiology and biotechnology , antibiotics , biochemistry , bacteria , biology , organic chemistry , genetics

The phenolic diterpene totarol had good antimicrobial activity against effluxing strains ofStaphylococcus aureus . Subinhibitory concentrations reduced the MICs of selected antibiotics, suggesting that it may also be an efflux pump inhibitor (EPI). A totarol-resistant mutant that overexpressednorA was created to separate antimicrobial from efflux inhibitory activity. Totarol reduced ethidium efflux from this strain by 50% at 15 μM (1/4× MIC), and combination studies revealed marked reductions in ethidium MICs. These data suggest that totarol is a NorA EPI as well as an antistaphylococcal antimicrobial agent.

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