Open AccessPrior Antibacterial Peptide-Mediated Inhibition of Protein Folding in Bacteria Mutes Resistance Enzymes
Author(s) -
László Ötvös,
Vanessa de Olivier Inacio,
John D. Wade,
Predrag Čudić
Publication year - 2006
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00205-06
Subject(s) - bacteria , antibiotics , ciprofloxacin , antibacterial peptide , microbiology and biotechnology , peptide , antimicrobial , kanamycin , antibacterial agent , antibiotic resistance , antibacterial activity , enzyme , chemistry , biology , biochemistry , genetics
The antimicrobial activity of amoxicillin against TEM-1-expressing strains could be fully recovered when bacteria were preincubated with sublethal doses of an antibacterial peptide derivative. Assays with the simultaneous administration of antibiotics or synergy assays with kanamycin or ciprofloxacin, where resistance development does not involve properly folded proteins, failed to yield similar results.