Multiple Drug Transporters Contribute to the Placental Transfer of Emtricitabine | Zendy

Qingquan Zeng | Zendy; Mengru Bai | Zendy; Cui Li | Zendy; Shuanghui Lu | Zendy; Zhiyuan Ma | Zendy; Yunchun Zhao | Zendy; Hui Zhou | Zendy; Huidi Jiang | Zendy; Dongli Sun | Zendy; Caihong Zheng | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Multiple Drug Transporters Contribute to the Placental Transfer of Emtricitabine

Author(s) -

Qingquan Zeng,

Mengru Bai,

Cui Li,

Shuanghui Lu,

Zhiyuan Ma,

Yunchun Zhao,

Hui Zhou,

Huidi Jiang,

Dongli Sun,

Caihong Zheng

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00199-19

Subject(s) - emtricitabine , drug , pharmacology , transporter , chemistry , medicine , biochemistry , virology , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy , gene

Emtricitabine (FTC) is a first-line antiviral drug recommended for the treatment of AIDS during pregnancy. We hypothesized that transporters located in the placenta contribute to FTC transfer across the blood-placenta barrier. BeWo cells, cell models with stable or transient expression of transporter genes, primary human trophoblast cells (PHTCs), and small interfering RNAs (siRNAs) were applied to demonstrate which transporters were involved.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research