A Phe389Leu Substitution in ErgA Confers Terbinafine Resistance in Aspergillus fumigatus | Zendy

Eleusa Maria Ferreira Rocha | Zendy; R. E. Gardiner | Zendy; S. Park | Zendy; Nilce Maria Martinez-Rossi | Zendy; David S. Perlin | Zendy

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A Phe389Leu Substitution in ErgA Confers Terbinafine Resistance in Aspergillus fumigatus

Author(s) -

Eleusa Maria Ferreira Rocha,

R. E. Gardiner,

S. Park,

Nilce Maria Martinez-Rossi,

David S. Perlin

Publication year - 2006

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00187-06

Subject(s) - aspergillus fumigatus , aspergillus nidulans , aspergillus , microbiology and biotechnology , terbinafine , biology , mutant , squalene monooxygenase , gene , genetics , biosynthesis , antifungal , itraconazole

Replacement of phenylalanine with leucine at position 391 in squalene epoxidase was identified as being responsible for terbinafine resistance in mutants ofAspergillus nidulans . The equivalent mutation was engineered into theergA gene ofAspergillus fumigatus , resulting in an F389L substitution that also conferred resistance to this pathogenic mold.

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