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Replacement of phenylalanine with leucine at position 391 in squalene epoxidase was identified as being responsible for terbinafine resistance in mutants ofAspergillus nidulans . The equivalent mutation was engineered into theergA gene ofAspergillus fumigatus , resulting in an F389L substitution that also conferred resistance to this pathogenic mold.

A Phe389Leu Substitution in ErgA Confers Terbinafine Resistance in Aspergillus fumigatus