Rapid Antibiotic Combination Testing for Carbapenem-Resistant Gram-Negative Bacteria within Six Hours Using ATP Bioluminescence | Zendy

Yiying Cai | Zendy; Celene L. Seah | Zendy; Hui Leck | Zendy; Tze-Peng Lim | Zendy; Jocelyn Qi-Min Teo | Zendy; Winnie Lee | Zendy; Thuan-Tong Tan | Zendy; Tse-Hsien Koh | Zendy; Pui Lai Rachel Ee | Zendy; Andrea LayHoon Kwa | Zendy

Open Access

Rapid Antibiotic Combination Testing for Carbapenem-Resistant Gram-Negative Bacteria within Six Hours Using ATP Bioluminescence

Author(s) -

Yiying Cai,

Celene L. Seah,

Hui Leck,

Tze-Peng Lim,

Jocelyn Qi-Min Teo,

Winnie Lee,

Thuan-Tong Tan,

Tse-Hsien Koh,

Pui Lai Rachel Ee,

Andrea LayHoon Kwa

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00183-18

Subject(s) - acinetobacter baumannii , bioluminescence , antibiotics , pseudomonas aeruginosa , klebsiella pneumoniae , acinetobacter , microbiology and biotechnology , bacteria , carbapenem , biology , enterobacteriaceae , gram , receiver operating characteristic , confidence interval , medicine , escherichia coli , biochemistry , genetics , gene

To guide the timely selection of antibiotic combinations against carbapenem-resistant Gram-negative bacteria (CR-GNB), anin vitro test with a short turnaround time is essential. We developed anin vitro ATP bioluminescence assay to determine effective antibiotic combinations against CR-GNB within 6 h.

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