Use of the Surgical Wound Infection Model To Determine the Efficacious Dosing Regimen of Retapamulin, a Novel Topical Antibiotic | Zendy

Stephen Rittenhouse | Zendy; Christine M. Singley | Zendy; Jennifer L. Hoover | Zendy; Roni Page | Zendy; David Payne | Zendy

Open Access

Use of the Surgical Wound Infection Model To Determine the Efficacious Dosing Regimen of Retapamulin, a Novel Topical Antibiotic

Author(s) -

Stephen Rittenhouse,

Christine M. Singley,

Jennifer L. Hoover,

Roni Page,

David Payne

Publication year - 2006

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00183-06

Subject(s) - dosing , mupirocin , medicine , antibiotics , staphylococcus aureus , fusidic acid , regimen , antibacterial agent , microbiology and biotechnology , methicillin resistant staphylococcus aureus , biology , bacteria , genetics

The effect of topically applied retapamulin ointment was evaluated using various dosing regimens in the Staphylococcus aureus and Streptococcus pyogenes wound infection model. Retapamulin (1%, wt/wt) was efficacious using twice-daily (b.i.d.) applications for 4 or 5 days. These data underpinned the decision to evaluate 1% retapamulin b.i.d. in clinical trials.

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