Penetration of Ertapenem into Muscle Measured by In Vivo Microdialysis in Mechanically Ventilated Patients | Zendy

I. Boyadjiev | Zendy; Audrey Boulaméry | Zendy; Nicolas Simon | Zendy; C. Martín | Zendy; Bernard Bruguerolle | Zendy; Marc Léone | Zendy

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Penetration of Ertapenem into Muscle Measured by In Vivo Microdialysis in Mechanically Ventilated Patients

Author(s) -

I. Boyadjiev,

Audrey Boulaméry,

Nicolas Simon,

C. Martín,

Bernard Bruguerolle,

Marc Léone

Publication year - 2011

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00180-11

Subject(s) - ertapenem , microdialysis , intensive care unit , in vivo , medicine , population , skeletal muscle , pharmacology , antibiotics , microbiology and biotechnology , biology , meropenem , central nervous system , environmental health , antibiotic resistance

Ertapenem at 1 g once daily has been suggested to be underdosed in intensive care unit (ICU) patients to attain optimal concentrations in target tissues. Therefore, our study aimed to assess the kinetics of ertapenem in plasma and skeletal muscle in ICU patients using microdialysis. Average muscle free-ertapenem concentrations were above the MIC values of targeted pathogens. In a few patients, the concentrations were below the MIC values. The clinical efficiency of ertapenem at 1 g once daily should be evaluated in a large population of ICU patients.

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