Sensitivity of White and Opaque Candida albicans Cells to Antifungal Drugs | Zendy

Veronica Craik | Zendy; Alexander D. Johnson | Zendy; Matthew B. Lohse | Zendy

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Sensitivity of White and Opaque Candida albicans Cells to Antifungal Drugs

Author(s) -

Veronica Craik,

Alexander D. Johnson,

Matthew B. Lohse

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00166-17

Subject(s) - candida albicans , microbiology and biotechnology , antifungal , sensitivity (control systems) , biology , medicine , engineering , electronic engineering

White and opaque cells ofCandida albicans have the same genome but differ in gene expression patterns, metabolic profiles, and host niche preferences. We tested whether these differences, which include the differential expression of drug transporters, resulted in different sensitivities to 27 antifungal agents. The analysis was performed in two different strain backgrounds; although there was strain-to-strain variation, only terbinafine hydrochloride and caspofungin showed consistent, 2-fold differences between white and opaque cells across both strains.

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