Galanin Message-Associated Peptide Suppresses Growth and the Budded-to-Hyphal-Form Transition ofCandida albicans | Zendy

Isabella Rauch | Zendy; Linda Lundström | Zendy; Markus Hell | Zendy; Wolfgang Sperl | Zendy; Barbara Kofler | Zendy

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Galanin Message-Associated Peptide Suppresses Growth and the Budded-to-Hyphal-Form Transition ofCandida albicans

Author(s) -

Isabella Rauch,

Linda Lundström,

Markus Hell,

Wolfgang Sperl,

Barbara Kofler

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00166-07

Subject(s) - candida albicans , galanin , peptide , innate immune system , corpus albicans , downregulation and upregulation , transition (genetics) , immune system , microbiology and biotechnology , defensin , biology , neuropeptide , immunology , gene , biochemistry , receptor

The expression of the mRNA encoding galanin message-associated peptide (GMAP) in human keratinocytes is upregulated by lipopolysaccharides and exposure to Candida albicans. GMAP has growth-inhibiting activity against C. albicans and inhibits the budded-to-hyphal-form transition, establishing GMAP as a possible new component of the innate immune system.

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