Spontaneously Arising Streptococcus mutans Variants with Reduced Susceptibility to Chlorhexidine Display Genetic Defects and Diminished Fitness | Zendy

Justin R. Kaspar | Zendy; Matthew J. Godwin | Zendy; Irina M. Velsko | Zendy; Vincent P. Richards | Zendy; Robert A. Burne | Zendy

Open Access

Spontaneously Arising Streptococcus mutans Variants with Reduced Susceptibility to Chlorhexidine Display Genetic Defects and Diminished Fitness

Author(s) -

Justin R. Kaspar,

Matthew J. Godwin,

Irina M. Velsko,

Vincent P. Richards,

Robert A. Burne

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00161-19

Subject(s) - streptococcus mutans , chlorhexidine , biology , genetics , microbiology and biotechnology , dentistry , medicine , bacteria

Chlorhexidine (CHX) has been used to control dental caries caused by acid-tolerant bacteria such asStreptococcus mutans since the 1970s. Repeat CHX exposure for other bacterial species results in the development of variants with reduced susceptibility that also become more resistant to other antimicrobials.

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