Drug Resistance Mutations in HIV-Infected Patients in the Spanish Drug Resistance Database Failing Tipranavir and Darunavir Therapy | Zendy

Eva Poveda | Zendy; Lourdes Anta | Zendy; José Luis Blanco | Zendy; José L. Casado | Zendy; Félix Gutiérrez | Zendy; Féderico García | Zendy; Juan Luís Gómez-Sirvent | Zendy; José Antonio Iribarren | Zendy; Vincent Soriano | Zendy; Carmen de Mendoza | Zendy

Open Access

Drug Resistance Mutations in HIV-Infected Patients in the Spanish Drug Resistance Database Failing Tipranavir and Darunavir Therapy

Author(s) -

Eva Poveda,

Lourdes Anta,

José Luis Blanco,

José L. Casado,

Félix Gutiérrez,

Féderico García,

Juan Luís Gómez-Sirvent,

José Antonio Iribarren,

Vincent Soriano,

Carmen de Mendoza

Publication year - 2010

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00160-10

Subject(s) - darunavir , drug resistance , medicine , drug , mutation , resistance mutation , virology , pharmacology , human immunodeficiency virus (hiv) , biology , antiretroviral therapy , genetics , viral load , gene , polymerase chain reaction , reverse transcriptase

The presence of resistance mutations in patients failing tipranavir or darunavir was examined at the national drug resistance database of the Spanish AIDS Research Network. Although mutations emerging during tipranavir and darunavir failures differed considerably, cross-resistance was found in up to half of the patients tested. Interestingly, mutation 54L, which is associated with tipranavir hypersusceptibility, was selected in half of the darunavir failures. Thus, resistance testing seems mandatory to ensure the benefit of the sequential use of these drugs.

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