Revised Interpretation of the Hain Lifescience GenoType MTBC To Differentiate Mycobacterium canettii and Members of the Mycobacterium tuberculosis Complex | Zendy

Chloé Loiseau | Zendy; Daniela Brites | Zendy; Irmgard Moser | Zendy; Francesc Coll | Zendy; Christine Pourcel | Zendy; Suelee RobbeAusterman | Zendy; Vincent Escuyer | Zendy; Kimberlee A. Musser | Zendy; Sharon J. Peacock | Zendy; Silke Feuerriegel | Zendy; Thomas A. Kohl | Zendy; Stefan Niemann | Zendy; Sébastien Gagneux | Zendy; Claudio U. Köser | Zendy

Open Access

Revised Interpretation of the Hain Lifescience GenoType MTBC To Differentiate Mycobacterium canettii and Members of the Mycobacterium tuberculosis Complex

Author(s) -

Chloé Loiseau,

Daniela Brites,

Irmgard Moser,

Francesc Coll,

Christine Pourcel,

Suelee RobbeAusterman,

Vincent Escuyer,

Kimberlee A. Musser,

Sharon J. Peacock,

Silke Feuerriegel,

Thomas A. Kohl,

Stefan Niemann,

Sébastien Gagneux,

Claudio U. Köser

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00159-19

Subject(s) - mycobacterium tuberculosis complex , mycobacterium tuberculosis , mycobacterium bovis , biology , mycobacterium , genotype , microbiology and biotechnology , tuberculosis , virology , genetics , gene , medicine , bacteria , pathology

Using 894 phylogenetically diverse genomes of theMycobacterium tuberculosis complex (MTBC), we simulatedin silico the ability of the Hain Lifescience GenoType MTBC assay to differentiate the causative agents of tuberculosis. Here, we propose a revised interpretation of this assay to reflect its strengths (e.g., it can distinguish some strains ofMycobacterium canettii and variants ofMycobacterium bovis that are not intrinsically resistant to pyrazinamide) and limitations (e.g.,Mycobacterium orygis cannot be differentiated fromMycobacterium africanum ).

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