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Using 894 phylogenetically diverse genomes of theMycobacterium tuberculosis complex (MTBC), we simulatedin silico the ability of the Hain Lifescience GenoType MTBC assay to differentiate the causative agents of tuberculosis. Here, we propose a revised interpretation of this assay to reflect its strengths (e.g., it can distinguish some strains ofMycobacterium canettii and variants ofMycobacterium bovis that are not intrinsically resistant to pyrazinamide) and limitations (e.g.,Mycobacterium orygis cannot be differentiated fromMycobacterium africanum ).

antimicrobial agents and chemotherapy

Revised Interpretation of the Hain Lifescience GenoType MTBC To Differentiate <i>Mycobacterium canettii</i> and Members of the Mycobacterium tuberculosis Complex

Revised Interpretation of the Hain Lifescience GenoType MTBC To Differentiate Mycobacterium canettii and Members of the Mycobacterium tuberculosis Complex