Profiling of PDR1 and MSH2 in Candida glabrata Bloodstream Isolates from a Multicenter Study in China | Zendy

Xin Hou | Zendy; Meng Xiao | Zendy; He Wang | Zendy; Shu-Ying Yu | Zendy; Ge Zhang | Zendy; Yanan Zhao | Zendy; Yingchun Xu | Zendy

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Profiling of PDR1 and MSH2 in Candida glabrata Bloodstream Isolates from a Multicenter Study in China

Author(s) -

Xin Hou,

Meng Xiao,

He Wang,

Shu-Ying Yu,

Ge Zhang,

Yanan Zhao,

Yingchun Xu

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00153-18

Subject(s) - candida glabrata , fluconazole , multilocus sequence typing , biology , microbiology and biotechnology , bloodstream infection , fungemia , genotype , typing , genotyping , genetics , antifungal , gene

Among 158Candida glabrata bloodstream isolates collected from numerous centers in China, a resistance to fluconazole was seen in 8.9%. Three isolates (1.9%) were resistant to all echinocandins. Multilocus sequence typing (MLST) revealed that sequence type 7 ([ST7] 65.8%) was the most common type, followed by ST3 (7.6%).PDR1 polymorphisms were associated with the acquisition of fluconazole resistance inC. glabrata isolates, whileMSH2 polymorphisms were associated with the STs and microsatellite genotypes, irrespective of fluconazole resistance.

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