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Among 158Candida glabrata bloodstream isolates collected from numerous centers in China, a resistance to fluconazole was seen in 8.9%. Three isolates (1.9%) were resistant to all echinocandins. Multilocus sequence typing (MLST) revealed that sequence type 7 ([ST7] 65.8%) was the most common type, followed by ST3 (7.6%).PDR1 polymorphisms were associated with the acquisition of fluconazole resistance inC. glabrata isolates, whileMSH2 polymorphisms were associated with the STs and microsatellite genotypes, irrespective of fluconazole resistance.

Profiling of PDR1 and MSH2 in Candida glabrata Bloodstream Isolates from a Multicenter Study in China